Dataset Information

Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum.

ABSTRACT: BACKGROUND:Pregnancy and childbirth are a period of high risk for women with bipolar disorder and involve difficult decisions particularly about continuing or stopping medications.AimsTo explore what clinical predictors may help to individualise the risk of perinatal recurrence in women with bipolar disorder. METHOD:Information was gathered retrospectively by semi-structured interview, questionnaires and case-note review from 887 women with bipolar disorder who have had children. Clinical predictors were selected using backwards stepwise logistic regression, conditional permutation random forests and reinforcement learning trees. RESULTS:Previous perinatal history of affective psychosis or depression was the most significant predictor of a perinatal recurrence (odds ratio (OR) = 8.5, 95% CI 5.04-14.82 and OR = 3.6, 95% CI 2.55-5.07 respectively) but even parous women with bipolar disorder without a previous perinatal mood episode were at risk following a subsequent pregnancy, with 7% developing postpartum psychosis. CONCLUSIONS:Previous perinatal history of affective psychosis or depression is the most important predictor of perinatal recurrence in women with bipolar disorder and can be used to individualise risk assessments.Declaration of interestNone.

SUBMITTER: Di Florio A

PROVIDER: S-EPMC6429257 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

ACCESS DATA

Publications

Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum.

Di Florio Arianna A Gordon-Smith Katherine K Forty Liz L Kosorok Michael R MR Fraser Christine C Perry Amy A Bethell Andrew A Craddock Nick N Jones Lisa L Jones Ian I

The British journal of psychiatry : the journal of mental science 20180901 3

<h4>Background</h4>Pregnancy and childbirth are a period of high risk for women with bipolar disorder and involve difficult decisions particularly about continuing or stopping medications.AimsTo explore what clinical predictors may help to individualise the risk of perinatal recurrence in women with bipolar disorder.<h4>Method</h4>Information was gathered retrospectively by semi-structured interview, questionnaires and case-note review from 887 women with bipolar disorder who have had children. ...[more]

PMID: 30113284

Similar Datasets

Project description:BackgroundBipolar disorder (BPD) is a common condition associated with significant morbidity and reduced quality of life. In addition to challenges caused by their mood symptoms, parents affected with BPD harbor concerns about the mental health of their children. Among adult parents who perceive themselves to have BPD, this study aims to examine participants' coping methods; identify predictors of adaptation; assess parental perceptions of risks for mood disorders among their children; and describe the relationships among illness appraisals, coping, adaptation to one's own illness, and perceived risk to one's children.MethodsParents who self-identified as having BPD completed a web-based survey that assessed dispositional optimism, coping, perceived illness severity, perceived etiology of BPD, perceived risk to offspring, and adaptation to BPD. Participants had at least one unaffected child who was 30 years of age or below.Results266 parents were included in the analysis. 87% of parents endorsed a "somewhat greater" or "much greater" risk for mood disorders in one's child(ren) than someone without a family history. Endorsing a genetic/familial etiology to BPD was positively correlated with perceived risk for mood disorders in children (rs?=?.3, p?<?0.01) and active coping with BDP (r?=?.2, p?<?0.01). Increased active coping (??=?0.4, p?<?0.001) and dispositional optimism (??=?0.3, p?<?0.001) were positively associated with better adaptation, while using denial coping was negatively associated with adaptation (??=?-0.3, p?<?0.001). The variables explained 55.2% of the variance in adaptation (F?=?73.2, p?<?0.001). Coping mediated the effect of perceived illness severity on adaptation.ConclusionsThese data inform studies of interventions that extend beyond symptom management and aim to improve the psychological wellbeing of parents with BPD. Interventions targeted at illness perceptions and those aimed at enhancing coping should be studied for positive effects on adaptation. Parents with BPD may benefit from genetic counseling to promote active coping with their condition, and manage worry about perceived risk to their children.

Dataset Information

Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum.

Publications

Stratification of the risk of bipolar disorder recurrences in pregnancy and postpartum.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure