A Facile Approach for Fabrication of Core-Shell Magnetic Molecularly Imprinted Nanospheres towards Hypericin.

ABSTRACT: By taking advantage of the self-polymerization of dopamine on the surface of magnetic nanospheres in weak alkaline Tris-HCl buffer solution, a facile approach was established to fabricate core-shell magnetic molecularly imprinted nanospheres towards hypericin (Fe₃O₄@PDA/Hyp NSs), via a surface molecular imprinting technique. The Fe₃O₄@PDA/Hyp NSs were characterized by FTIR, TEM, DLS, and BET methods, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the Fe₃O₄@PDA/Hyp NSs synthesized under the optimized conditions showed a high adsorption capacity (Q = 18.28 mg/g) towards hypericin. The selectivity factors of Fe₃O₄@PDA/Hyp NSs were about 1.92 and 3.55 towards protohypericin and emodin, respectively. In addition, the approach established in this work showed good reproducibility for fabrication of Fe₃O₄@PDA/Hyp.

SUBMITTER: Cheng W 

PROVIDER: S-EPMC6431851 | biostudies-other | 2017 Apr

REPOSITORIES: biostudies-other