Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC6437640 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Zhu Liangsong L Wang Jianfeng J Kong Wen W Huang Jiwei J Dong Baijun B Huang Yiran Y Xue Wei W Zhang Jin J
Acta pharmaceutica Sinica. B 20181030 2
Histone lysine-specific demethylase 1 (LSD1) has been implicated in the disease progression of several types of solid tumors. This study provides the first evidence showing that LSD1 overexpression occurred in 62.6% (224/358) of clear cell renal cell carcinomas (ccRCC). LSD1 expression was associated with the progression of ccRCC, as indicated by TNM stage (<i>P</i>=0.006), especially tumor stage (<i>P</i>=0.017) and lymph node metastasis (<i>P</i>=0.030). High LSD1 expression proved to be an in ...[more]