Ontology highlight
ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC6442581 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Ji Yahui Y Qi Dongyuan D Li Linmei L Su Haoran H Li Xiaojie X Luo Yong Y Sun Bo B Zhang Fuyin F Lin Bingcheng B Liu Tingjiao T Lu Yao Y
Proceedings of the National Academy of Sciences of the United States of America 20190311 13
Extracellular vesicles (EVs) are important intercellular mediators regulating health and diseases. Conventional methods for EV surface marker profiling, which was based on population measurements, masked the cell-to-cell heterogeneity in the quantity and phenotypes of EV secretion. Herein, by using spatially patterned antibody barcodes, we realized multiplexed profiling of single-cell EV secretion from more than 1,000 single cells simultaneously. Applying this platform to profile human oral squa ...[more]