Ontology highlight
ABSTRACT:
SUBMITTER: Sabol RA
PROVIDER: S-EPMC6470828 | biostudies-other | 2019 Mar
REPOSITORIES: biostudies-other
Sabol Rachel A RA Beighley Adam A Giacomelli Paulina P Wise Rachel M RM Harrison Mark A A MAA O'Donnnell Ben A BA Sullivan Brianne N BN Lampenfeld Jacob D JD Matossian Margarite D MD Bratton Melyssa R MR Wang Guangdi G Collins-Burow Bridgette M BM Burow Matthew E ME Bunnell Bruce A BA
International journal of molecular sciences 20190320 6
Adipose stem cells (ASCs) play an essential role in tumor microenvironments. These cells are altered by obesity (obASCs) and previous studies have shown that obASCs secrete higher levels of leptin. Increased leptin, which upregulates estrogen receptor alpha (ERα) and aromatase, enhances estrogen bioavailability and signaling in estrogen receptor positive (ER⁺) breast cancer (BC) tumor growth and metastasis. In this study, we evaluate the effect of obASCs on ER⁺BC outside of the ERα signaling axi ...[more]