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Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica.


ABSTRACT: Panax ginseng Meyer cv. Silvatica (PGS), which is also known as "Lin-Xia-Shan-Shen" or "Zi-Hai" in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15⁻20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (1), ginsengenin-S2 (2), ginsenoside-S3 (3), ginsenoside-S4 (4), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways.

SUBMITTER: Qi Z 

PROVIDER: S-EPMC6470847 | biostudies-other | 2019 Mar

REPOSITORIES: biostudies-other

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Four Novel Dammarane-Type Triterpenoids from Pearl Knots of <i>Panax ginseng</i> Meyer cv. Silvatica.

Qi Zeng Z   Li Zhuo Z   Guan Xuewa X   Wang Cuizhu C   Wang Fang F   Li Pingya P   Liu Jinping J  

Molecules (Basel, Switzerland) 20190323 6


<i>Panax ginseng</i> Meyer cv. Silvatica (PGS), which is also known as "Lin-Xia-Shan-Shen" or "Zi-Hai" in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15⁻20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (<b>1</b>), ginsengenin-S2 (<b>2</b>), ginsenoside-S3 (<b>3</b>), ginsenoside-S4 (<b>4</b>), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly  ...[more]

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