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Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis.


ABSTRACT: Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga Dictyota spiralis has led to the isolation of spiralyde A (1), a new dolabellane aldehyde, along with other five known related diterpenes (2⁻6). Their structures were determined by HRESIMS, 1D and 2D NMR spectroscopy, and comparison with data reported in the literature. The antiparasitic activity of all compounds was evaluated. Spiralyde A (1) and the known compound 3,4-epoxy-7,18-dolabelladiene (2) were the most active compounds against Leishmania amazonensis and Trypanosoma cruzi. Spiralyde A (1) was the most potent compound, comparable to benznidazole, the reference drug for trypanocidal activity.

SUBMITTER: Chiboub O 

PROVIDER: S-EPMC6471066 | biostudies-other | 2019 Mar

REPOSITORIES: biostudies-other

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Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga <i>Dictyota spiralis</i>.

Chiboub Olfa O   Sifaoui Ines I   Lorenzo-Morales Jacob J   Abderrabba Manef M   Mejri Mondher M   Fernández José Javier JJ   Piñero José E JE   Díaz-Marrero Ana R AR  

Marine drugs 20190325 3


Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga <i>Dictyota spiralis</i> has led to the isolation of spiralyde A (<b>1</b>), a new dolabellane aldehyde, along with other five known related diterpenes (<b>2</b>⁻<b>6</b>). Their structures were determined by HRESIMS, 1D and 2D NMR spectroscopy, and comparison with data reported in the literature. The antiparasitic activity of all compounds was evaluated. Spiralyde A (<b>1</b>) and the known compound 3,4-epoxy-7,18-  ...[more]

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