Ontology highlight
ABSTRACT:
SUBMITTER: Pakshir P
PROVIDER: S-EPMC6478854 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Nature communications 20190423 1
Macrophage (Mϕ)-fibroblast interactions coordinate tissue repair after injury whereas miscommunications can result in pathological healing and fibrosis. We show that contracting fibroblasts generate deformation fields in fibrillar collagen matrix that provide far-reaching physical cues for Mϕ. Within collagen deformation fields created by fibroblasts or actuated microneedles, Mϕ migrate towards the force source from several hundreds of micrometers away. The presence of a dynamic force source in ...[more]