Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis.
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ABSTRACT:
SUBMITTER: Bowler MA
PROVIDER: S-EPMC6488810 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Publications
Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis.
Bowler Meghan A MA Raddatz Michael A MA Johnson Camryn L CL Lindman Brian R BR Merryman W David WD
JACC. Basic to translational science 20190222 2
Calcific aortic valve disease is a progressive fibrocalcific process that can only be treated with valve replacement. Cadherin-11 has recently been identified as a potential therapeutic target for calcific aortic valve disease. The already approved drug celecoxib, a cyclooxygenase-2 inhibitor, binds cadherin-11, and was investigated as a therapeutic against calcific aortic valve disease. Unexpectedly, celecoxib treatment led to hallmarks of myofibroblast activation and calcific nodule formation ...[more]
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