Ontology highlight
ABSTRACT:
SUBMITTER: Radzio-Basu J
PROVIDER: S-EPMC6494879 | biostudies-other | 2019 May
REPOSITORIES: biostudies-other
Radzio-Basu Jessica J Council Olivia O Cong Mian-Er ME Ruone Susan S Newton Alicia A Wei Xierong X Mitchell James J Ellis Shanon S Petropoulos Christos J CJ Huang Wei W Spreen William W Heneine Walid W García-Lerma J Gerardo JG
Nature communications 20190501 1
A long-acting injectable formulation of the HIV integrase inhibitor cabotegravir (CAB-LA) is currently in clinical development for PrEP. Although the long plasma half-life of CAB-LA is an important attribute for PrEP, it also raises concerns about drug resistance emergence if someone becomes infected with HIV, or if PrEP is initiated during undiagnosed acute infection. Here we use a macaque model of SHIV infection to model risks of drug resistance to CAB-LA PrEP. Six macaques infected with SHIV ...[more]