Ontology highlight
ABSTRACT:
SUBMITTER: Wrackmeyer U
PROVIDER: S-EPMC6494904 | biostudies-other | 2019 May
REPOSITORIES: biostudies-other
Scientific reports 20190501 1
The Coxsackievirus and adenovirus receptor (CAR) is essential for normal electrical conductance in the heart, but its role in the postnatal brain is largely unknown. Using brain specific CAR knockout mice (KO), we discovered an unexpected role of CAR in neuronal communication. This includes increased basic synaptic transmission at hippocampal Schaffer collaterals, resistance to fatigue, and enhanced long-term potentiation. Spontaneous neurotransmitter release and speed of endocytosis are increas ...[more]