Ontology highlight
ABSTRACT:
SUBMITTER: Ponatshego PL
PROVIDER: S-EPMC6500286 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Ponatshego Ponego Lloyd PL Lawrence David Stephen DS Youssouf Nabila N Molloy Sile F SF Alufandika Melanie M Bango Funeka F Boulware David R DR Chawinga Chimwemwe C Dziwani Eltas E Gondwe Ebbie E Hlupeni Admire A Hosseinipour Mina C MC Kanyama Cecilia C Meya David B DB Mosepele Mosepele M Muthoga Charles C Muzoora Conrad K CK Mwandumba Henry H Ndhlovu Chiratidzo E CE Rajasingham Radha R Sayed Sumaya S Shamu Shepherd S Tsholo Katlego K Tugume Lillian L Williams Darlisha D Maheswaran Hendramoorthy H Shiri Tinevimbo T Boyer-Chammard Timothée T Loyse Angela A Chen Tao T Wang Duolao D Lortholary Olivier O Lalloo David G DG Meintjes Graeme G Jaffar Shabbar S Harrison Thomas S TS Jarvis Joseph N JN Niessen Louis Wilhelmus LW
BMJ open 20190401 4
<h4>Introduction</h4>Cryptococcal meningitis is responsible for around 15% of all HIV-related deaths globally. Conventional treatment courses with amphotericin B require prolonged hospitalisation and are associated with multiple toxicities and poor outcomes. A phase II study has shown that a single high dose of liposomal amphotericin may be comparable to standard treatment. We propose a phase III clinical endpoint trial comparing single, high-dose liposomal amphotericin with the WHO recommended ...[more]