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Sometimes Less Is Not Enough: A Commentary on Greiff et al. (2015).

ABSTRACT: In this commentary, I discuss some critical issues in the study by Greiff, S.; Stadler, M.; Sonnleitner, P.; Wolff, C.; Martin, R., "Sometimes less is more: Comparing the validity of complex problem solving measures", Intelligence 2015, 50, 100-113. I conclude that-counter to the claims made in the original study-the specific study design was not suitable for deriving conclusions about the validity of different complex problem-solving (CPS) measurement approaches. Furthermore, a more elaborate consideration of previous CPS research was found to challenge Greiff et al.'s conclusions even further. Therefore, I argue that researchers should be aware of the differences between several kinds of CPS assessment tools and conceptualizations when the validity of CPS assessment tools is examined in future research.

SUBMITTER: Kretzschmar A

PROVIDER: S-EPMC6526428 | biostudies-other | 2017 Jan

REPOSITORIES: biostudies-other

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Sometimes Less Is Not Enough: A Commentary on Greiff et al. (2015).

Kretzschmar André A

Journal of Intelligence 20170105 1

In this commentary, I discuss some critical issues in the study by Greiff, S.; Stadler, M.; Sonnleitner, P.; Wolff, C.; Martin, R., "Sometimes less is more: Comparing the validity of complex problem solving measures", Intelligence 2015, 50, 100-113. I conclude that-counter to the claims made in the original study-the specific study design was not suitable for deriving conclusions about the validity of different complex problem-solving (CPS) measurement approaches. Furthermor ...[more]

PMID: 31162395

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Project description:Aneuploidy is a hallmark of tumor cells and yet the precise relationship between aneuploidy and a cell’s proliferative ability, or cellular fitness, has remained elusive. In this study we have combined a detailed analysis of aneuploid clones isolated from laboratory-evolved populations of Saccharomyces cerevisiae with a systematic, genome-wide screen for the fitness effects of telomeric amplifications to address the relationship between aneuploidy and cellular fitness. We found that aneuploid clones rise to high population frequencies in nutrient-limited evolution experiments and show increased fitness relative to wild-type. Direct competition experiments confirmed that three out of four aneuploid events isolated from evolved populations were themselves sufficient to improve fitness. To expand the scope beyond this small number of exemplars, we created a genome-wide collection of >1,800 diploid yeast strains each containing a different telomeric amplicon (Tamp) ranging in size from 0.4 to 1,000kb. Using pooled competition experiments in nutrient-limited chemostats followed by high-throughput sequencing of strain-identifying barcodes, we determined the fitness effects of these >1,800 Tamps under three different conditions. Our data revealed that the fitness landscape explored by telomeric amplifications is much broader than that explored by single-gene amplifications. As also observed in the evolved clones, we found the fitness effects of most Tamps to be condition specific with a minority showing common effects in all three conditions. By integrating our data with previous work that examined the fitness effects of single-gene amplifications genome wide, we found that a small number of genes within each Tamp are centrally responsible for each Tamp’s fitness effects. Our genome-wide Tamp screen confirmed that telomeric amplifications identified in laboratory-evolved populations generally increased fitness. Our results show that Tamps are mutations that produce large, typically condition-dependent changes in fitness that are important drivers of increased fitness in asexually evolving populations. Each of these arrays is a Comparative Genomic Hybridization experiment to detect copy number differences between a reference strain and a strain of interest.

Dataset Information

Sometimes Less Is Not Enough: A Commentary on Greiff et al. (2015).

Publications

Sometimes Less Is Not Enough: A Commentary on Greiff et al. (2015).

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