Optical Resolution of Rimantadine.
Ontology highlight
ABSTRACT:
SUBMITTER: Han J
PROVIDER: S-EPMC6539882 | biostudies-other | 2019 May
REPOSITORIES: biostudies-other
Publications
Optical Resolution of Rimantadine.
Han Jianlin J Takeda Ryosuke R Sato Tatsunori T Moriwaki Hiroki H Abe Hidenori H Izawa Kunisuke K Soloshonok Vadim A VA
Molecules (Basel, Switzerland) 20190512 9
This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (<i>S</i>)-rimantadine using (<i>R</i>)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies. ...[more]
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