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Mechanical properties, safety and resistance values of Lemgruber® elastic tubing.

ABSTRACT: BACKGROUND:Lemgruber® elastic tubing has been used as an adjunct to exercise training with positive effects in healthy adults and in patients with chronic lung disease. Despite its benefits, there is a lack of information on the specific resistance, elongation, reproducibility and safety of the different types of Lemgruber® elastic tubing. OBJECTIVES:The primary outcome was to assess the length-resistance relation (E/R) of five Lemgruber® elastic tubing of different diameters. Secondary outcomes included the development of reference equations of resistance according to elongation of Lemgruber® elastic tubing types and; the description of Lemgruber® elastic tubing safety and; the description of elongation of Lemgruber® elastic tubing using a clinically useful outcome (i.e. range of motion, in degrees). METHODS:The relation between elongation and resistance of Lemgruber® elastic tubing was investigated in a laboratory environment. Secondly, reference equations for the resistance according to the elongation in each Lemgruber® elastic tubing were calculated. Finally, the elongation of the tubing during movements in different degrees of range of motion were estimated using mathematical models, so that the resistance provided by the tubing for any exercise could be predicted. RESULTS:Lemgruber® elastic tubing provided a large array of resistance varying from 3±0.1Newtons (N) to 537±13N (mean±standard deviation). The maximal resistance deemed safe for each of the five Lemgruber® elastic tubing were: 173±25N, 280±23N, 409±40N, 395±37N and 537±13N. Reference equations had nearly perfect predictive power (r2=0.99) for all polynomial non-linear models (p<0.001 for all). CONCLUSIONS:Lemgruber elastic tubing progressively increased resistance with increased elongation. The large array of resistances delivered by Lemgruber® elastic tubing, along with its safety and good estimation of reference values, support its use in clinical practice.

SUBMITTER: Lima FF

PROVIDER: S-EPMC6546839 | biostudies-other | 2019 Jan - Feb

REPOSITORIES: biostudies-other

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Mechanical properties, safety and resistance values of Lemgruber<sup>®</sup> elastic tubing.

Lima Fabiano Francisco de FF Camillo Carlos Augusto CA Reis Elton Aparecido Prado Dos EAPD Job Aldo Eloizo AE Silva Bruna Spolador de Alencar BSA Topalovic Marko M Ramos Dionei D Ramos Ercy Mara Cipulo EMC

Brazilian journal of physical therapy 20180717 1

<h4>Background</h4>Lemgruber<sup>®</sup> elastic tubing has been used as an adjunct to exercise training with positive effects in healthy adults and in patients with chronic lung disease. Despite its benefits, there is a lack of information on the specific resistance, elongation, reproducibility and safety of the different types of Lemgruber<sup>®</sup> elastic tubing.<h4>Objectives</h4>The primary outcome was to assess the length-resistance relation (E/R) of five Lemgruber<sup>®</sup> elastic t ...[more]

PMID: 30077519

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Project description:Tissue-engineered blood vessels (TEVs) are typically produced using the pulsatile, uniaxial circumferential stretch to mechanically condition and strengthen the arterial grafts. Despite improvements in the mechanical integrity of TEVs after uniaxial conditioning, these tissues fail to achieve critical properties of native arteries such as matrix content, collagen fiber orientation, and mechanical strength. As a result, uniaxially loaded TEVs can result in mechanical failure, thrombus, or stenosis on implantation. In planar tissue equivalents such as artificial skin, biaxial loading has been shown to improve matrix production and mechanical properties. To date however, multiaxial loading has not been examined as a means to improve mechanical and biochemical properties of TEVs during culture. Therefore, we developed a novel bioreactor that utilizes both circumferential and axial stretch that more closely simulates loading conditions in native arteries, and we examined the suture strength, matrix production, fiber orientation, and cell proliferation. After 3 months of biaxial loading, TEVs developed a formation of mature elastic fibers that consisted of elastin cores and microfibril sheaths. Furthermore, the distinctive features of collagen undulation and crimp in the biaxial TEVs were absent in both uniaxial and static TEVs. Relative to the uniaxially loaded TEVs, tissues that underwent biaxial loading remodeled and realigned collagen fibers toward a more physiologic, native-like organization. The biaxial TEVs also showed increased mechanical strength (suture retention load of 303?±?14.53?g, with a wall thickness of 0.76?±?0.028?mm) and increased compliance. The increase in compliance was due to combinatorial effects of mature elastic fibers, undulated collagen fibers, and collagen matrix orientation. In conclusion, biaxial stretching is a potential means to regenerate TEVs with improved matrix production, collagen organization, and mechanical properties.

Dataset Information

Mechanical properties, safety and resistance values of Lemgruber® elastic tubing.

Publications

Mechanical properties, safety and resistance values of Lemgruber<sup>®</sup> elastic tubing.

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