Ontology highlight
ABSTRACT:
SUBMITTER: Luscher-Firzlaff J
PROVIDER: S-EPMC6547667 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Lüscher-Firzlaff Juliane J Chatain Nicolas N Kuo Chao-Chung CC Braunschweig Till T Bochyńska Agnieszka A Ullius Andrea A Denecke Bernd B Costa Ivan G IG Koschmieder Steffen S Lüscher Bernhard B
Scientific reports 20190604 1
Post-translational modifications of core histones participate in controlling the expression of genes. Methylation of lysine 4 of histone H3 (H3K4), together with acetylation of H3K27, is closely associated with open chromatin and gene transcription. H3K4 methylation is catalyzed by KMT2 lysine methyltransferases that include the mixed-lineage leukemia 1-4 (MLL1-4) and SET1A and B enzymes. For efficient catalysis, all six require a core complex of four proteins, WDR5, RBBP5, ASH2L, and DPY30. We ...[more]