Ontology highlight
ABSTRACT:
SUBMITTER: Kanji S
PROVIDER: S-EPMC6557810 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Kanji Suman S Das Manjusri M Joseph Matthew M Aggarwal Reeva R Sharma Sudarshana M SM Ostrowski Michael M Pompili Vincent J VJ Mao Hai-Quan HQ Das Hiranmoy H
Scientific reports 20190610 1
Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34<sup>+</sup> cells (henceforth CD34<sup>+</sup> cells) effective therapy, tested in cutaneous wounds developed in streptozotocin-induced diabetic NOD/SCID mice. We show that systemic administration of CD34<sup>+</sup> cells homed to the wound site and signif ...[more]