Unknown

Dataset Information

0

The humanistic burden of advanced non-small cell lung cancer (NSCLC) in Europe: a real-world survey linking patient clinical factors to patient and caregiver burden.


ABSTRACT: PURPOSE:Advanced non-small cell lung cancer (aNSCLC) impacts the lives of patients and their caregivers. This analysis examined the association between patient clinical characteristics and patient and caregiver humanistic burden. METHODS:Data for patients with aNSCLC and their informal caregivers in France, Germany and Italy, were collected between May 2015 and June 2016 via chart review and patient and caregiver surveys. Patients and caregivers completed validated instruments to evaluate their health state (EuroQol-5-dimensions-3-levels [EQ-5D-3L]), work and activity impairment (Work Productivity Activity Impairment [WPAI]) and health-related quality of life (HRQoL; European Organisation for Research and treatment of Cancer Quality of Life Questionnaire [EORTC QLQ-C30]). Caregivers also completed the Zarit Burden Interview (ZBI). Univariate and regression analyses were stratified by patient Eastern Cooperative Group Performance Status (ECOG-PS 0, 1, 2 or 3/4). RESULTS:In total, 1030 patients and 427 accompanying informal caregivers participated. Regression analyses indicated that patients reported lower EQ-5D-3L utility index, EQ-VAS and EORTC QLQ-C30 global health status and greater work and activity impairment with worsening ECOG-PS (all p < 0.05). Caregivers also reported greater activity impairment and higher ZBI scores with worsening ECOG-PS of the patient they were providing care for (all p < 0.05). CONCLUSIONS:As patients' functionality deteriorates as measured by the ECOG-PS, so do their outcomes related to health utility, work productivity, activity impairment and HRQoL. This deterioration is also reflected in increased caregiver burden and activity impairment. There is a need for interventions to maintain patients' physical function to relieve the humanistic burden of both patients and caregivers.

SUBMITTER: Wood R 

PROVIDER: S-EPMC6571083 | biostudies-other | 2019 Jul

REPOSITORIES: biostudies-other

altmetric image

Publications

The humanistic burden of advanced non-small cell lung cancer (NSCLC) in Europe: a real-world survey linking patient clinical factors to patient and caregiver burden.

Wood Robert R   Taylor-Stokes Gavin G   Smith Fiona F   Chaib Carlos C  

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20190302 7


<h4>Purpose</h4>Advanced non-small cell lung cancer (aNSCLC) impacts the lives of patients and their caregivers. This analysis examined the association between patient clinical characteristics and patient and caregiver humanistic burden.<h4>Methods</h4>Data for patients with aNSCLC and their informal caregivers in France, Germany and Italy, were collected between May 2015 and June 2016 via chart review and patient and caregiver surveys. Patients and caregivers completed validated instruments to  ...[more]

Similar Datasets

| S-EPMC6092048 | biostudies-literature
| S-EPMC8293640 | biostudies-literature
| S-EPMC7001541 | biostudies-literature
| S-EPMC9282872 | biostudies-literature
| S-EPMC7340862 | biostudies-literature
| S-EPMC3854518 | biostudies-literature
2022-09-26 | PXD037076 |
| S-EPMC8507718 | biostudies-literature
| S-EPMC8728458 | biostudies-literature
| S-EPMC7850085 | biostudies-literature