Ontology highlight
ABSTRACT:
SUBMITTER: Cheffings TH
PROVIDER: S-EPMC6589908 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Cheffings Thomas H TH Burroughs Nigel J NJ Balasubramanian Mohan K MK
Molecular biology of the cell 20190213 8
In many eukaryotes, cytokinesis is facilitated by the contraction of an actomyosin ring (AMR). The exact mechanisms that lead to this contractility are unknown, although some models posit that actin turnover in the AMR is essential. The effect of reduced actin dynamics during AMR formation has been well studied in Schizosaccharomyces pombe; however, the corresponding effects on AMR contraction are not well understood. By using mutants of the fission yeast actin severing protein Adf1, we observed ...[more]