Ontology highlight
ABSTRACT:
SUBMITTER: Amato T
PROVIDER: S-EPMC6591170 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Scientific reports 20190624 1
In this paper, we report studies concerning thrombin binding aptamer (TBA) dimeric derivatives in which the 3'-ends of two TBA sequences have been joined by means of linkers containing adenosine or thymidine residues and/or a glycerol moiety. CD and electrophoretic investigations indicate that all modified aptamers are able to form G-quadruplex domains resembling that of the parent TBA structure. However, isothermal titration calorimetry measurements of the aptamer/thrombin interaction point to ...[more]