Ontology highlight
ABSTRACT:
SUBMITTER: Greco SH
PROVIDER: S-EPMC6608084 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Greco Stephanie H SH Mahmood Syed Kashif SK Vahle Anne-Kristin AK Ochi Atsuo A Batel Jennifer J Deutsch Michael M Barilla Rocky R Seifert Lena L Pachter H Leon HL Daley Donnele D Torres-Hernandez Alejandro A Hundeyin Mautin M Mani Vishnu R VR Miller George G
Journal of leukocyte biology 20160108 1
Regulation of Toll-like receptor responses is critical for limiting tissue injury and autoimmunity in both sepsis and sterile inflammation. We found that Mincle, a C-type lectin receptor, regulates proinflammatory Toll-like receptor 4 signaling. Specifically, Mincle ligation diminishes Toll-like receptor 4-mediated inflammation, whereas Mincle deletion or knockdown results in marked hyperresponsiveness to lipopolysaccharide in vitro, as well as overwhelming lipopolysaccharide-mediated inflammati ...[more]