TADOSS: computational estimation of tandem domain swap stability.
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ABSTRACT:
SUBMITTER: Lafita A
PROVIDER: S-EPMC6612889 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Publications
TADOSS: computational estimation of tandem domain swap stability.
Lafita Aleix A Tian Pengfei P Best Robert B RB Bateman Alex A
Bioinformatics (Oxford, England) 20190701 14
<h4>Summary</h4>Proteins with highly similar tandem domains have shown an increased propensity for misfolding and aggregation. Several molecular explanations have been put forward, such as swapping of adjacent domains, but there is a lack of computational tools to systematically analyze them. We present the TAndem DOmain Swap Stability predictor (TADOSS), a method to computationally estimate the stability of tandem domain-swapped conformations from the structures of single domains, based on prev ...[more]
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