AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice.
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ABSTRACT:
SUBMITTER: Uraki R
PROVIDER: S-EPMC6614468 | biostudies-other | 2019
REPOSITORIES: biostudies-other
Publications
AgBR1 antibodies delay lethal <i>Aedes aegypti</i>-borne West Nile virus infection in mice.
Uraki Ryuta R Hastings Andrew K AK Brackney Doug E DE Armstrong Philip M PM Fikrig Erol E
NPJ vaccines 20190708
West Nile virus (WNV) is transmitted by mosquitoes and can cause severe disease, including meningoencephalitis. AgBR1 is a mosquito salivary protein that enhances <i>Aedes aegypti</i> mosquito-borne Zika virus pathogenesis in mice. Here, we show that AgBR1 antibodies reduce the initial West Nile viral load and delay lethal infection after feeding by an infected <i>Aedes aegypti</i> mosquito. Targeting AgBR1 may therefore be incorporated into strategies to prevent mosquito-transmitted West Nile v ...[more]
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