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Adversity and cooperation in heterogeneous pairs.

ABSTRACT: This paper provides a game-theoretic model of the effect of higher adversity on the evolution of cooperation. The focus lies on how this effect of higher adversity is impacted when there is transient, non-genetic heterogeneity in the form of differences in the players' capabilities of contributing to the public good, in the benefits they obtain from the public good, or in their cooperation costs. A framework is provided that identifies the common mechanisms that are at work across two models of cooperation (jointly producing a public good, and jointly defending an existing public good), and across the mentioned types of heterogeneity. With relatively small heterogeneity, higher adversity generates a common-enemy effect for large cooperation costs and a deterrence effect for small cooperation costs. Yet, these results on the effect of higher adversity are completely reversed for relatively large heterogeneity.

SUBMITTER: De Jaegher K

PROVIDER: S-EPMC6629845 | biostudies-other | 2019 Jul

REPOSITORIES: biostudies-other

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Adversity and cooperation in heterogeneous pairs.

De Jaegher Kris K

Scientific reports 20190715 1

This paper provides a game-theoretic model of the effect of higher adversity on the evolution of cooperation. The focus lies on how this effect of higher adversity is impacted when there is transient, non-genetic heterogeneity in the form of differences in the players' capabilities of contributing to the public good, in the benefits they obtain from the public good, or in their cooperation costs. A framework is provided that identifies the common mechanisms that are at work across two models of ...[more]

PMID: 31308402

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Project description:BackgroundSupervised learning and many stochastic methods for predicting protein-protein interactions require both negative and positive interactions in the training data set. Unlike positive interactions, negative interactions cannot be readily obtained from interaction data, so these must be generated. In protein-protein interactions and other molecular interactions as well, taking all non-positive interactions as negative interactions produces too many negative interactions for the positive interactions. Random selection from non-positive interactions is unsuitable, since the selected data may not reflect the original distribution of data.ResultsWe developed a bootstrapping algorithm for generating a negative data set of arbitrary size from protein-protein interaction data. We also developed an efficient boosting algorithm for finding interacting motif pairs in human and virus proteins. The boosting algorithm showed the best performance (84.4% sensitivity and 75.9% specificity) with balanced positive and negative data sets. The boosting algorithm was also used to find potential motif pairs in complexes of human and virus proteins, for which structural data was not used to train the algorithm. Interacting motif pairs common to multiple folds of structural data for the complexes were proven to be statistically significant. The data set for interactions between human and virus proteins was extracted from BOND and is available at http://virus.hpid.org/interactions.aspx. The complexes of human and virus proteins were extracted from PDB and their identifiers are available at http://virus.hpid.org/PDB_IDs.html.ConclusionWhen the positive and negative training data sets are unbalanced, the result via the prediction model tends to be biased. Bootstrapping is effective for generating a negative data set, for which the size and distribution are easily controlled. Our boosting algorithm could efficiently predict interacting motif pairs from protein interaction and sequence data, which was trained with the balanced data sets generated via the bootstrapping method.

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Adversity and cooperation in heterogeneous pairs.

Publications

Adversity and cooperation in heterogeneous pairs.

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