Ontology highlight
ABSTRACT:
SUBMITTER: Shah NR
PROVIDER: S-EPMC6630667 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Shah Nirav R NR Bulitta Jürgen B JB Kinzig Martina M Landersdorfer Cornelia B CB Jiao Yuanyuan Y Sutaria Dhruvitkumar S DS Tao Xun X Höhl Rainer R Holzgrabe Ulrike U Kees Frieder F Stephan Ulrich U Sörgel Fritz F
Pharmaceutics 20190618 6
The pharmacokinetics in patients with cystic fibrosis (CF) has long been thought to differ considerably from that in healthy volunteers. For highly protein bound β-lactams, profound pharmacokinetic differences were observed between comparatively morbid patients with CF and healthy volunteers. These differences could be explained by body weight and body composition for β-lactams with low protein binding. This study aimed to develop a novel population modeling approach to describe the pharmacokine ...[more]