Ontology highlight
ABSTRACT:
SUBMITTER: Ewing LE
PROVIDER: S-EPMC6630875 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Ewing Laura E LE McGill Mitchell R MR Yee Eric U EU Quick Charles M CM Skinner Charles M CM Kennon-McGill Stefanie S Clemens Melissa M Vazquez Joel H JH McCullough Sandra S SS Williams D Keith DK Kutanzi Kristy R KR Walker Larry A LA ElSohly Mahmoud A MA James Laura P LP Gurley Bill J BJ Koturbash Igor I
Molecules (Basel, Switzerland) 20190617 12
The goal of this study was to investigate the potential for a cannabidiol-rich cannabis extract (CRCE) to interact with the most common over-the-counter drug and the major known cause of drug-induced liver injury-acetaminophen (APAP)-in aged female CD-1 mice. Gavaging mice with 116 mg/kg of cannabidiol (CBD) [mouse equivalent dose (MED) of 10 mg/kg of CBD] in CRCE delivered with sesame oil for three consecutive days followed by intraperitoneally (i.p.) acetaminophen (APAP) administration (400 mg ...[more]