Ontology highlight
ABSTRACT:
SUBMITTER: Norwitz ER
PROVIDER: S-EPMC6679081 | biostudies-other | 2019 Jun
REPOSITORIES: biostudies-other
Norwitz Errol R ER McNeill Gabriel G Kalyan Akshita A Rivers Elizabeth E Ahmed Ebad E Meng Ling L Vu Phikhanh P Egbert Melissa M Shapira Marlene M Kobara Katie K Parmar Sheetal S Goel Shruti S Prins Sarah A SA Aruh Israel I Persico Nicola N Robins Jared C JC Kirshon Brian B Demko Zachary P ZP Ryan Allison A Billings Paul R PR Rabinowitz Matthew M Benn Peter P Martin Kimberly A KA Hedriana Herman L HL
Journal of clinical medicine 20190628 7
We analyzed maternal plasma cell-free DNA samples from twin pregnancies in a prospective blinded study to validate a single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) for zygosity, fetal sex, and aneuploidy. Zygosity was evaluated by looking for either one or two fetal genome complements, fetal sex was evaluated by evaluating Y-chromosome loci, and aneuploidy was assessed through SNP ratios. Zygosity was correctly predicted in 100% of cases (93/93; 95% confidence inter ...[more]