Ontology highlight
ABSTRACT:
SUBMITTER: He X
PROVIDER: S-EPMC6715679 | biostudies-other | 2019 Aug
REPOSITORIES: biostudies-other
He Xiaolin X Zhang Tianzhou T Tolosa Monica M Goru Santosh Kumar SK Chen Xiaolan X Misra Paraish S PS Robinson Lisa A LA Yuen Darren A DA
Scientific reports 20190829 1
Our understanding of diabetic kidney disease pathogenesis has been hampered by the lack of easily generated pre-clinical animal models that faithfully recapitulate critical features of human disease. While most standard animal models develop manifestations of early stage diabetic injury such as hyperfiltration and mesangial matrix expansion, only a select few develop key late stage features such as interstitial fibrosis and reduced glomerular filtration rate. An underlying theme in these late st ...[more]