Ontology highlight
ABSTRACT:
SUBMITTER: Tsutsumi K
PROVIDER: S-EPMC6722881 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Tsutsumi Kaori K Sasase Tatsuya T
FEBS open bio 20190730 9
Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by which polyP affects mitochondrial metabolism to promote cellular calcification in MC3T3-E1 osteoblastic cells. The cellular content of adenosine triphosphate (ATP) was diminished one d ...[more]