Ontology highlight
ABSTRACT:
SUBMITTER: King SB
PROVIDER: S-EPMC6724739 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
King S Bradley SB Toufexis Donna J DJ Hammack Sayamwong E SE
Stress (Amsterdam, Netherlands) 20170614 5
Stressor exposure is associated with the onset and severity of many psychopathologies that are more common in women than men. Moreover, the maladaptive expression and function of stress-related hormones have been implicated in these disorders. Evidence suggests that PACAP has a critical role in the stress circuits mediating stress-responding, and PACAP may interact with sex hormones to contribute to sex differences in stress-related disease. In this review, we describe the role of the PACAP/PAC1 ...[more]