Ontology highlight
ABSTRACT:
SUBMITTER: Palmer AK
PROVIDER: S-EPMC6731336 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Palmer Allyson K AK Gustafson Birgit B Kirkland James L JL Smith Ulf U
Diabetologia 20190827 10
Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been described and recently entered clinical trials. In this review, we explore the biologica ...[more]