The perioperative administration of dexamethasone and infection (PADDI) trial protocol: rationale and design of a pragmatic multicentre non-inferiority study.
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SUBMITTER: Corcoran TB
PROVIDER: S-EPMC6731833 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
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The perioperative administration of dexamethasone and infection (PADDI) trial protocol: rationale and design of a pragmatic multicentre non-inferiority study.
Corcoran Tomás B TB Myles Paul S PS Forbes Andrew B AB O'Loughlin Ed E Leslie Kate K Story David D Short Timothy G TG Chan Matthew Tv MT Coutts Pauline P Sidhu Jaspreet J Cheng Allen C AC Bach Leon A LA Ho Kwok M KM
BMJ open 20190906 9
<h4>Introduction</h4>The intraoperative administration of dexamethasone for prophylaxis against postoperative nausea and vomiting is a common and recommended practice. The safety of the administration of this immunosuppressive agent at a time of significant immunological disruption has not been rigorously evaluated in terms of infective complications.<h4>Methods/analysis</h4>This is a pragmatic, multicentre, randomised, controlled, non-inferiority trial. A total of 8880 patients undergoing elect ...[more]
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