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Discontinuation, persistence and adherence to subcutaneous biologics delivered via a homecare route to Scottish adults with rheumatic diseases: a retrospective study.


ABSTRACT: OBJECTIVES:To understand patterns of subcutaneous (SC) biologics use over time in adults with inflammatory rheumatic musculoskeletal diseases receiving a homecare delivery service. DESIGN:Retrospective cohort. SETTING:Patients in secondary care receiving SC biologics in the largest Scottish Health Board. PARTICIPANTS:A new bespoke cohort was created from routine data gathered as part of a health board Homecare Service Database. Patients over 18 years who received a supply of SC biologic from January 2012 to May 2015 with a diagnosis for rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondylitis (AS) were included. OUTCOMES MEASURED:A standardised framework was applied by measuring discontinuation rates, persistence using Kaplan-Meier analysis and Cox regression and adherence using medication refill adherence (MRA) and compliance rate (CR). RESULTS:751 patients were identified (AS: 105, PsA: 227, RA: 419) of whom 89.3% had more than one biologic delivery (median days' follow-up: AS: 494; PsA: 544; RA: 529) and 83.2% did not switch biologic. For all conditions, approximately half were persistent on their index biologic (52% AS, 54% PsA, 48%RA). Of patients who discontinued treatment, the majority reinitiated with the same biologic (19% AS, 18% PsA and 21% RA). Overall adherence during the period of treatment was over 80% when calculated using MRA (median %MRA: AS: 84.0%, PsA: 85.0%, RA: 82.4%) or CR (median %CR: AS: 96.6%, PsA: 97%, RA: 96.6%). CONCLUSION:Use of linked routine data is a sustainable pathway to enable ongoing evaluation of biologics use. A more consistent approach to studying use (discontinuation, persistence and adherence metrics) should be adopted to enable comparability of studies.

SUBMITTER: Alvarez-Madrazo S 

PROVIDER: S-EPMC6731860 | biostudies-other | 2019 Sep

REPOSITORIES: biostudies-other

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Discontinuation, persistence and adherence to subcutaneous biologics delivered via a homecare route to Scottish adults with rheumatic diseases: a retrospective study.

Alvarez-Madrazo Samantha S   Kavanagh Kimberley K   Siebert Stefan S   Semple Yvonne Y   Godman Brian B   Maciel Almeida Alessandra A   Acurcio Francisco de Assis FA   Bennie Marion M  

BMJ open 20190904 9


<h4>Objectives</h4>To understand patterns of subcutaneous (SC) biologics use over time in adults with inflammatory rheumatic musculoskeletal diseases receiving a homecare delivery service.<h4>Design</h4>Retrospective cohort.<h4>Setting</h4>Patients in secondary care receiving SC biologics in the largest Scottish Health Board.<h4>Participants</h4>A new bespoke cohort was created from routine data gathered as part of a health board Homecare Service Database. Patients over 18 years who received a s  ...[more]

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