Ontology highlight
ABSTRACT:
SUBMITTER: Bilous M
PROVIDER: S-EPMC6736889 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Bilous M M Serdjebi C C Boyer A A Tomasini P P Pouypoudat C C Barbolosi D D Barlesi F F Chomy F F Benzekry S S
Scientific reports 20190910 1
Brain metastases (BMs) are associated with poor prognosis in non-small cell lung cancer (NSCLC), but are only visible when large enough. Therapeutic decisions such as whole brain radiation therapy would benefit from patient-specific predictions of radiologically undetectable BMs. Here, we propose a mathematical modeling approach and use it to analyze clinical data of BM from NSCLC. Primary tumor growth was best described by a gompertzian model for the pre-diagnosis history, followed by a tumor g ...[more]