Ontology highlight
ABSTRACT:
SUBMITTER: Ramakrishnan S
PROVIDER: S-EPMC6748105 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Ramakrishnan Swathi S Granger Victoria V Rak Monika M Hu Qiang Q Attwood Kristopher K Aquila Lanni L Krishnan Nithya N Osiecki Rafal R Azabdaftari Gissou G Guru Khurshid K Chatta Gurkamal G Gueron Geraldine G McNally Lacey L Ohm Joyce J Wang Jianmin J Woloszynska Anna A
Cell death and differentiation 20190128 10
Lysine-specific demethylase 6A (KDM6A) and members of the Switch/Sucrose Non-Fermentable (SWI/SNF) family are known to counteract the activity of Enhancer of Zeste Homolog 2 (EZH2), which is often overexpressed and is associated with poor prognosis in muscle-invasive bladder cancer. Here we provide evidence that alterations in chromatin modifying enzymes, including KDM6A and members of the SWI/SNF complex, are frequent in muscle-invasive bladder cancer. We exploit the loss of function mutations ...[more]