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Models of persecutory delusions: a mechanistic insight into the early stages of psychosis.


ABSTRACT: Identifying robust markers for predicting the onset of psychosis has been a key challenge for early detection research. Persecutory delusions are core symptoms of psychosis, and social cognition is particularly impaired in first-episode psychosis patients and individuals at risk for developing psychosis. Here, we propose new avenues for translation provided by hierarchical Bayesian models of behaviour and neuroimaging data applied in the context of social learning to target persecutory delusions. As it comprises a mechanistic model embedded in neurophysiology, the findings of this approach may shed light onto inference and neurobiological causes of transition to psychosis.

SUBMITTER: Diaconescu AO 

PROVIDER: S-EPMC6756090 | biostudies-other | 2019 Sep

REPOSITORIES: biostudies-other

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Models of persecutory delusions: a mechanistic insight into the early stages of psychosis.

Diaconescu Andreea Oliviana AO   Hauke Daniel Jonas DJ   Borgwardt Stefan S  

Molecular psychiatry 20190510 9


Identifying robust markers for predicting the onset of psychosis has been a key challenge for early detection research. Persecutory delusions are core symptoms of psychosis, and social cognition is particularly impaired in first-episode psychosis patients and individuals at risk for developing psychosis. Here, we propose new avenues for translation provided by hierarchical Bayesian models of behaviour and neuroimaging data applied in the context of social learning to target persecutory delusions  ...[more]

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