Ontology highlight
ABSTRACT:
SUBMITTER: Alfonzo E
PROVIDER: S-EPMC6761868 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Chemical science 20190705 33
Herein, we detail a unified synthetic approach to the classical lignan family of natural products that hinges on divergence from a common intermediate that was strategically identified from nature's biosynthetic blueprints. Efforts toward accessing the common intermediate through a convergent and modular approach resulted in the discovery of a sterically encumbered photoredox catalyst that can selectively generate carbonyl ylides from electron-rich epoxides. These can undergo concerted [3 + 2] d ...[more]