Ontology highlight
ABSTRACT:
SUBMITTER: Kretzmann JA
PROVIDER: S-EPMC6761875 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Kretzmann Jessica A JA Evans Cameron W CW Moses Colette C Sorolla Anabel A Kretzmann Amy L AL Wang Edina E Ho Diwei D Hackett Mark J MJ Dessauvagie Benjamin F BF Smith Nicole M NM Redfern Andrew D AD Waryah Charlene C Norret Marck M Iyer K Swaminathan KS Blancafort Pilar P
Chemical science 20190627 33
Aberrant gene expression is a hallmark of cancer. Although transcription is traditionally considered 'undruggable', the development of CRISPR-associated protein 9 (Cas9) systems offers enormous potential to rectify cancer-associated transcriptional abnormalities in malignant cells. However delivery of this technology presents a critical challenge to overcome in order to realize clinical translation for cancer therapy. In this article we demonstrate for the first time, a fully synthetic strategy ...[more]