Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TB
PROVIDER: S-EPMC6769668 | biostudies-other | 2019 Aug
REPOSITORIES: biostudies-other
Brain sciences 20190826 9
Stathmin (<i>STMN</i>), a microtubule-destabilizing factor, can regulate fear, anxiety, and learning. Social defeat stress (SDS) has detrimental effects on mental health and increases the risk of various psychiatric diseases. This study investigated the effects of <i>STMN1</i> gene knockout (KO) on behavioral parameters and dopaminergic markers using an SDS mouse model. The <i>STMN1</i> KO mice showed anxious hyperactivity, impaired object recognition, and decreased levels of neutral and social ...[more]