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Highlights in Resistance Mechanism Pathways for Combination Therapy.

ABSTRACT: Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support and orient the development of innovative strategies for anticancer combination therapy. The ultimate goal is to highlight possible strategies of chemotherapy combinations based on the signaling pathways associated with the resistance mechanisms against anticancer drugs to maximize the selective induction of cancer cell death. We consider this review an extensive compilation of updated known information on chemotherapy resistance mechanisms to promote new combination therapies to be to discussed and tested.

SUBMITTER: Delou JMA

PROVIDER: S-EPMC6770082 | biostudies-other | 2019 Aug

REPOSITORIES: biostudies-other

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Highlights in Resistance Mechanism Pathways for Combination Therapy.

Delou João M A JMA Souza Alana S O ASO Souza Leonel C M LCM Borges Helena L HL

Cells 20190830 9

Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support ...[more]

PMID: 31480389

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