Liver Microphysiological Systems for Predicting and Evaluating Drug Effects.
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ABSTRACT:
SUBMITTER: Ribeiro AJS
PROVIDER: S-EPMC6771674 | biostudies-other | 2019 Jul
REPOSITORIES: biostudies-other
Publications
Liver Microphysiological Systems for Predicting and Evaluating Drug Effects.
Ribeiro Alexandre J S AJS Yang Xinning X Patel Vikram V Madabushi Rajnikanth R Strauss David G DG
Clinical pharmacology and therapeutics 20190604 1
Liver plays a major role in drug metabolism and is one of the main sites of drug adverse effects. Microphysiological systems (MPS), also known as organs-on-a-chip, are a class of microfluidic platforms that recreate properties of tissue microenvironments. Among different properties, the liver microenvironment is three-dimensional, fluid flows around its cells, and different cell types regulate its function. Liver MPS aim to recreate these properties and enable drug testing and measurement of fun ...[more]
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