Ontology highlight
ABSTRACT:
SUBMITTER: Colombo M
PROVIDER: S-EPMC6771824 | biostudies-other | 2019 Jul
REPOSITORIES: biostudies-other
Colombo Matteo M Pessey Ombeline O Marcia Marco M
FEBS letters 20190529 14
Polycomb repressive complex 1 (PRC1) catalyses monoubiquitination of histone H2A on Lys119, promoting gene silencing. Cells at different developmental stages and in different tissues express different PRC1 isoforms. The topology, subunit composition, structural architecture and molecular mechanism of most of these isoforms are still poorly characterized. Here, we have purified a PRC1 isoform comprising subunits RING1B, PCGF2, CBX2 and PHC2, two stable subcomplexes (RING1B-PCGF2 and RING1B-PHC2) ...[more]