Ontology highlight
ABSTRACT:
SUBMITTER: Xi X
PROVIDER: S-EPMC6779874 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Xi Xiaonan X Liu Ning N Wang Qianqian Q Chu Yahui Y Yin Zheng Z Ding Yahui Y Lu Yaxin Y
Cell death & disease 20191007 10
PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the treatment of glioblastoma (GBM). However, the detailed molecular mechanism of ACT001 is still unclear. In this study, we investigated the effects of ACT001 on glioma cell proliferation and clarified its mechanism. We discovered that PAI-1 was the direct target of ACT001 by a cellular thermal shift assay. Then, the i ...[more]