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Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life.


ABSTRACT: Background:While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults, no data about these parameters are available in perinatally-infected patients with very long-lasting HIV infection. Methods:We compared thymic and bone marrow output, telomere length (measured by Real-Time PCR) and T-cell receptor repertoire (determined by spectratyping) of 21 perinatally HIV-infected subjects (with a median of 27 years of infection) with those of 19 age-matched non-perinatally HIV-infected patients and 40 healthy controls. All patients received a combined antiretroviral therapy. Results:While thymic and bone marrow output were not different among the analyzed groups, telomere length in peripheral blood cells and T-cell receptor diversity were significantly lower in HIV-perinatally and non-perinatally infected individuals compared to healthy controls. Conclusions:In HIV-infected subjects, a normal thymic output together with a reduced telomere length and a restricted T-cell receptor repertoire could be explained by the shift of newly produced cells into memory subsets. This phenomenon may allow to control viral infection and maintain peripheral homeostasis.

SUBMITTER: Paghera S 

PROVIDER: S-EPMC6791008 | biostudies-other | 2019

REPOSITORIES: biostudies-other

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Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life.

Paghera S S   Quiros-Roldan E E   Sottini A A   Properzi M M   Castelli F F   Imberti L L  

Immunity & ageing : I & A 20191013


<h4>Background</h4>While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults, no data about these parameters are available in perinatally-infected patients with very long-lasting HIV infection.<h4>Methods</h4>We compared thymic and bone marrow output, telomere length (measured by Real-Time PCR) and T-cell receptor repertoire (determined by spectra  ...[more]

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