Ontology highlight
ABSTRACT:
SUBMITTER: Jenzer M
PROVIDER: S-EPMC6805809 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Jenzer Maximilian M Keß Peter P Nientiedt Cathleen C Endris Volker V Kippenberger Maximilian M Leichsenring Jonas J Stögbauer Fabian F Haimes Josh J Mishkin Skyler S Kudlow Brian B Kaczorowski Adam A Zschäbitz Stefanie S Volckmar Anna-Lena AL Sültmann Holger H Jäger Dirk D Duensing Anette A Schirmacher Peter P Hohenfellner Markus M Grüllich Carsten C Stenzinger Albrecht A Duensing Stefan S
Cancer immunology, immunotherapy : CII 20190923 10
Defects in DNA damage repair caused by mutations in BRCA1/2, ATM or other genes have been shown to play an important role in the development and progression of prostate cancer. The influence of such mutations on anti-tumor immunity in prostate cancer, however, is largely unknown. To better understand the correlation between BRCA1/2 mutations and the immune phenotype in prostate cancer, we characterized the immune infiltrate of eight BRCA2-mutated tumors in comparison with eight BRCA1/2 wild-type ...[more]