Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6806670 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Zhang Yu Y Kontos Christopher D CD Annex Brian H BH Popel Aleksander S AS
iScience 20191003
The angiopoietin-Tie signaling pathway is an important vascular signaling pathway involved in angiogenesis, vascular stability, and quiescence. Dysregulation in the pathway is linked to the impairments in vascular function associated with many diseases, including cancer, ocular diseases, systemic inflammation, and cardiovascular diseases. The present study uses a computational signaling pathway model validated against experimental data to quantitatively study various mechanistic aspects of the a ...[more]