Ontology highlight
ABSTRACT:
SUBMITTER: Wagner A
PROVIDER: S-EPMC6808227 | biostudies-other | 2019 Sep
REPOSITORIES: biostudies-other
Wagner Alessa A Alan Betül B Yilmaz Dilay D Ahmad Mubashir M Liu Peng P Tangudu Naveen Kumar NK Tuckermann Jan P JP Vujic Spasic Maja M
JBMR plus 20190726 9
One of the most prevalent genetic iron overload disorders in Caucasians is caused by mutations in the <i>HFE</i> gene. Both <i>HFE</i> patients and <i>Hfe</i>-mouse models develop a progressive accumulation of iron in the parenchymal cells of various tissues, eventually resulting in liver cirrhosis, hepatocellular carcinoma, cardiomyopathies, hypogonadism, and other pathologies. Clinical data and preclinical models have brought considerable attention to the correlation between iron overload and ...[more]