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Three New Compounds from the Actinomycete Actinocorallia aurantiaca.

ABSTRACT: Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1-3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC50 values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC50 value of 35.9 μM, and a selective index higher than 13.3.

SUBMITTER: Han KY

PROVIDER: S-EPMC6814668 | biostudies-other | 2019 Oct

REPOSITORIES: biostudies-other

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Three New Compounds from the Actinomycete Actinocorallia aurantiaca.

Han Kai-Yue KY Wu Xing X Jiang Chenglin C Huang Rong R Li Zheng-Hui ZH Feng Tao T Chen He-Ping HP Liu Ji-Kai JK

Natural products and bioprospecting 20190916 5

Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivati ...[more]

PMID: 31529277

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