SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development.
Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TA
PROVIDER: S-EPMC6817685 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Publications
SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development.
Nguyen Tan A TA Bieging-Rolett Kathryn T KT Putoczki Tracy L TL Wicks Ian P IP Attardi Laura D LD Pang Ken C KC
iScience 20190910
RNautophagy is a newly described type of selective autophagy whereby cellular RNAs are transported into lysosomes for degradation. This process involves the transmembrane protein SIDT2, which transports double-stranded RNA (dsRNA) across the endolysosomal membrane. We previously demonstrated that SIDT2 is a transcriptional target of p53, but its role in tumorigenesis, if any, is unclear. Unexpectedly, we show here that Sidt2<sup>-/-</sup> mice with concurrent oncogenic Kras<sup>G12D</sup> activa ...[more]
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