Ontology highlight
ABSTRACT:
SUBMITTER: Kollmer M
PROVIDER: S-EPMC6820800 | biostudies-other | 2019 Oct
REPOSITORIES: biostudies-other
Nature communications 20191029 1
The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer's disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid fibrils from meningeal Alzheimer's brain tissue and their structural analysis with cryo-electron microscopy. We show that these fibrils are polymorphic but consist of similarly structured protofilaments. Brain derived Aβ amyloid fibrils are righ ...[more]